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Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
Published on: June 12, 2021
Lactate and other biomarkers as treatment target in cardiogenic shock
1Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Heart Center Lübeck, Lübeck, Germany.
Insights
Biomarkers are crucial for managing cardiogenic shock, a severe complication of heart attacks. Established markers like lactate and creatinine remain vital for patient monitoring and prognosis, outperforming newer options in recent studies.
Area of Science:
- Cardiology
- Biomedical Science
- Critical Care Medicine
Background:
- Cardiogenic shock is a life-threatening complication of acute myocardial infarction with limited therapeutic advancements.
- Early revascularization has not significantly improved outcomes in recent decades.
- Biomarkers play a critical role in the diagnosis, monitoring, and management of cardiogenic shock.
Purpose of the Study:
- To review the role and impact of biomarkers in cardiogenic shock.
- To assess the prognostic value of various biomarkers in patients with cardiogenic shock.
- To highlight the importance of biomarkers in guiding therapeutic decisions and understanding disease pathophysiology.
Main Methods:
- Review of recent clinical trials and literature on biomarkers in cardiogenic shock.
- Analysis of the prognostic significance of established versus novel biomarkers.
- Evaluation of the utility of biomarkers in patient monitoring and treatment selection.
Main Results:
- Numerous biomarkers have been linked to prognosis in cardiogenic shock.
- Standard monitoring parameters like serum lactate and creatinine demonstrated superior prognostic impact compared to novel markers in recent trials.
- Established biomarkers remain the most important for monitoring patients.
Conclusions:
- Biomarkers are essential for the diagnosis, monitoring, and management of cardiogenic shock.
- Established biomarkers like lactate and creatinine are critical for prognosis and patient management.
- Further investigation of biomarkers can enhance understanding of cardiogenic shock pathophysiology and guide treatment strategies.
Purpose Of Review:
Cardiogenic shock remains beside sudden cardiac death the most outcome relevant complication of acute myocardial infarction. Over the last two decades as confirmation of the benefit of early revascularization no further relevant improvement in outcome could be achieved. Biomarkers are important for diagnosis, monitoring, and management in cardiogenic shock patients.
Recent Findings:
A bunch of different biomarkers have been associated with prognosis in patients with cardiogenic shock. In routine use standard parameters such as serum lactate or serum creatinine are still most important in monitoring these patients. These established markers outperformed novel markers in prognostic impact in recent trials.
Summary:
Biomarkers serve as important treatment targets and may help physicians in therapeutic decision-making. Furthermore, the complex pathophysiology of cardiogenic shock may be better understood by investigation of different biomarkers.
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