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Dermatofibrosarcoma protuberans: our 10-year experience on 80 patients
Xiaobo Zhou1, Di Sun1, Yang Liu2
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Affiliated to Shanghai JiaoTong University School of Medicine, Center for Specialty Strategy Research of Shanghai JiaoTong University China Hospital Development Institute, Shanghai, PR China.
The Journal of Dermatological Treatment
|May 23, 2019
Summary
Achieving clean surgical margins is crucial for preventing dermatofibrosarcoma protuberans (DFSP) recurrence. Wide margin excision and Mohs surgery are recommended treatments for this rare soft tissue sarcoma.
Area of Science:
- Oncology
- Dermatology
- Surgical Pathology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare, aggressive soft tissue sarcoma.
- High recurrence rates present a significant clinical challenge in DFSP management.
Purpose of the Study:
- To analyze clinicopathologic factors of DFSP.
- To review treatment outcomes and recurrence rates based on surgical methods.
Main Methods:
- Retrospective evaluation of 80 DFSP patients treated between 2007-2017.
- Comparison of recurrence rates following local excision, wide margin excision, and Mohs surgery.
- Classification of DFSP into classical and transformed subtypes.
Main Results:
- Wide margin excision (margins >3cm) significantly reduced recurrence compared to local excision.
- No recurrence was observed in 10 patients treated with Mohs surgery.
- Transformed DFSP exhibited a higher recurrence tendency.
Conclusions:
- Attaining clean surgical margins is essential for preventing DFSP recurrence.
- Mohs surgery is a recommended treatment modality for DFSP due to its efficacy in preventing recurrence.
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