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Related Concept Videos

pre-mRNA Processing02:01

pre-mRNA Processing

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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
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mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
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The Proteasome02:18

The Proteasome

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Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
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Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

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The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...
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Initiation of Translation02:33

Initiation of Translation

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Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
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Nuclear Export of mRNA02:31

Nuclear Export of mRNA

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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Related Experiment Video

Updated: Jan 24, 2026

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Case 266: Pontine Tegmental Cap Dysplasia.

Chris J Cadman1, Lyndsay Fraser1, Claire McArthur1

  • 1From the Departments of Radiology (C.J.C., C.M.) and Otorhinolaryngology (L.F.), University Hospital Crosshouse, Kilmarnock, Scotland.

Radiology
|May 23, 2019
PubMed
Summary

A 1-year-old boy with profound sensorineural hearing loss received a cochlear implant. This case highlights cochlear implantation for severe hearing loss and developmental delay in infants.

Area of Science:

  • Pediatric Otolaryngology
  • Neuroscience
  • Ophthalmology

Background:

  • A 1-year-old boy presented with bilateral profound sensorineural hearing loss diagnosed neonatally.
  • Despite hearing aid use from 3 months, no behavioral responses were observed, indicating limited efficacy.
  • The child also exhibited mild developmental delays in motor milestones.

Observation:

  • Normal tympanic membranes and physical examination ruled out syndromic features.
  • Ophthalmological assessment revealed bilateral anesthetic corneas with abrasions, necessitating a tarsorrhaphy.
  • Auditory brainstem testing confirmed profound hearing loss with no responses in either ear.

Findings:

  • Magnetic Resonance Imaging (MRI) of the temporal lobe and brain, along with thin-section Computed Tomography (CT) of the temporal bones, were performed for cochlear implant assessment.

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  • The patient underwent successful left cochlear implantation.
  • Implications:

    • Cochlear implantation is a viable option for infants with profound sensorineural hearing loss unresponsive to hearing aids.
    • This case underscores the importance of multidisciplinary assessment, including ophthalmology, for complex pediatric cases.
    • Early intervention with cochlear implants can potentially improve auditory outcomes and support developmental progress in affected children.