Related Experiment Video
Updated: Jan 24, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Squamous cell carcinoma with perineural involvement in nevus sebaceus
Shaw T Locke1, William C Schaffenburg2, Jennifer P Breedlove3
12nd Battalion, 506th Infantry Regiment, Fort Campbell, Kentucky, USA.
Abstract:
Nevus sebaceus (NS), also known as an organoid nevus, is a congenital skin hamartoma involving the pilosebaceous unit, epidermis, and adnexa, frequently occurring in the scalp area. During childhood, the lesion remains unchanged but may subsequently increase in size during puberty in response to hormonal release, with possible tumor development. We report a case of squamous cell carcinoma (SCC) development in an NS with histologic evidence of perineural involvement on the anterior central scalp of a 13-year-old adolescent girl. We also review the management and prognosis.
Related Concept Videos
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...
What is Cell Signaling?
Batteries and Fuel Cells
What are Cells?
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Tissues
Concentration Cells
Consider the following voltaic cell:

