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Author Spotlight: Advancements in Multichannel Extracellular Recording for Studying Neuronal Activity in Freely Moving Mice
Published on: May 26, 2023
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A wireless miniScope for deep brain imaging in freely moving mice
Giovanni Barbera1, Bo Liang1, Lifeng Zhang1
1Neural Engineering Unit, Behavior Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA.
Journal of Neuroscience Methods
|May 23, 2019
Summary
Researchers developed a miniature wireless fluorescence microscope (miniScope) for high-resolution in vivo neural activity recording. This wearable device enables simultaneous multi-animal brain imaging, overcoming limitations of wired systems.
Area of Science:
- Neuroscience
- Bioengineering
- Microscopy
Background:
- Growing interest in microcircuit-level neuronal activity studies.
- Advancements in wearable miniature in vivo imaging systems.
- Improvements in size, cost, resolution, and signal-to-noise ratio of microscopes.
Purpose of the Study:
- To develop a miniature wireless fluorescence microscope (miniScope).
- To enable high-resolution, single-cell level recording of brain neural activity.
- To facilitate simultaneous in vivo imaging in freely moving animals.
Main Methods:
- Development of a wireless miniature fluorescence microscope (miniScope).
- Integration of onboard FPGA and Micro SD card storage.
- Utilized a battery backpack for power supply.
Main Results:
- Simultaneous recording of hundreds of medium spiny neurons (MSNs) in mice.
- Achieved excellent spatial and temporal resolutions in dorsal striatum recordings.
- Demonstrated simultaneous recording from multiple freely moving mice.
Conclusions:
- The wireless miniScope overcomes limitations of cabled systems.
- Enables simultaneous multi-animal in vivo imaging, expanding behavioral experiment possibilities.
- Potential future applications in freely behaving small primates.
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