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Published on: September 13, 2018
NCCN Guidelines Updates: Management of Muscle-Invasive Bladder Cancer
Abstract:
The treatment landscape of bladder cancer has changed rapidly over the past several years. The 2019 version of the NCCN Guidelines has integrated changes to tumor staging that reflect an updated understanding of the natural history of the disease and will affect how patients are treated. Further, 5 PD-1/PD-L1 immune checkpoint inhibitors (ICIs) are approved for the treatment of bladder cancer. The FDA has limited use of ICIs as monotherapy in the first-line treatment of metastatic and advanced disease for patients who are platinum-ineligible or are cisplatin-ineligible with high PD-L1 expression and are candidates for ICIs. Ongoing predictive biomarker development and validation are needed in bladder cancer; the development of better biomarkers will be key in patient selections for therapy going forward.
Insights
Bladder cancer treatment is evolving with updated staging and new immune checkpoint inhibitors (ICIs). Biomarker development is crucial for selecting patients for these advanced therapies.
Area of Science:
- Oncology
- Immunotherapy
- Urologic Oncology
Background:
- The treatment landscape for bladder cancer has undergone significant recent changes.
- Updated NCCN Guidelines reflect a revised understanding of bladder cancer staging and natural history.
- Five PD-1/PD-L1 immune checkpoint inhibitors (ICIs) are now approved for bladder cancer treatment.
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