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The microdosimetric extension in TOPAS: development and comparison with published data.

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Dosimetry

Background:

  • Microdosimetric energy deposition is key for modeling relative biological effectiveness (RBE) in proton and ion radiation therapy.
  • Despite its importance, microdosimetry remains underutilized in clinical practice.
  • Advancements in detector technology and Monte Carlo (MC) simulations present new opportunities for microdosimetry.

Purpose of the Study:

  • To develop and validate a microdosimetric extension for the TOPAS Monte Carlo simulation platform.
  • To enable detailed simulation of microdosimetric spectra and calculation of RBE.
  • To address the growing interest and underutilization of microdosimetry in radiation therapy.

Main Methods:

  • Developed a microdosimetric extension for TOPAS.
  • Implemented functionality for simulating microdosimetric spectra and secondary particle contributions.
  • Integrated methods for calculating RBE using biological weighting functions and the microdosimetric kinetic (MK) model.
  • Validated simulation results against published experimental data for spherical and cylindrical tissue equivalent proportional counters (TEPCs) and a solid-state microdosimeter.

Main Results:

  • The TOPAS microdosimetric extension successfully simulated microdosimetric spectra.
  • Simulations covered the range from the plateau region to the distal tail of the Bragg curve.
  • Results showed good agreement with published experimental data and other simulation findings for various microdosimeter types.
  • The extension facilitates RBE determination through established models.

Conclusions:

  • The TOPAS microdosimetric extension is a valuable tool for advancing radiation therapy research.
  • It accurately simulates microdosimetric spectra, supporting RBE modeling.
  • The tool can help bridge the gap between microdosimetry research and clinical application in particle therapy.