Acute Tubulointerstitial Nephritis: A Case Report on Rare Adverse Effect of Pembrolizumab
Sijan Basnet1, Rashmi Dhital2, Biswaraj Tharu3
1Department of Internal Medicine, Reading Hospital, 420 S Fifth Avenue, West Reading, PA 19611, USA. sijan.basnet@towerhealth.org.
Abstract:
Pembrolizumab is a novel immune checkpoint inhibitor approved for use in non-small cell lung carcinoma. There have been a few cases that have associated adverse renal outcomes with pembrolizumab. We present a case of acute kidney injury in a patient on pembrolizumab who was noted to have acute tubulointerstitial nephritis on renal biopsy. Pembrolizumab was discontinued and the patient was started on long-term corticosteroids with a taper. Her renal function improved partially with treatment.
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