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Updated: Jan 24, 2026

Visual and Microscopic Evaluation of Streptomyces Developmental Mutants
Published on: September 12, 2018
Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces
Xiachang Wang1, Muhammad Abbas2, Yinan Zhang1
1Jiangsu Key Laboratory for Functional Substances of Chinese Medicine , Nanjing University of Chinese Medicine , Nanjing 210023 , People's Republic of China.
Abstract:
The structures and bioactivities of three unprecedented fused 5-hydroxyquinoxaline/alpha-keto acid amino acid metabolites (baraphenazines A-C, 1-3), two unique diastaphenazine-type metabolites (baraphenazines D and E, 4 and 5) and two new phenazinolin-type (baraphenazines F and G, 6 and 7) metabolites from the Himalayan isolate Streptomyces sp. PU-10A are reported. This study highlights the first reported bacterial strain capable of producing diastaphenazine-type, phenazinolin-type, and izumiphenazine A-type metabolites and presents a unique opportunity for the future biosynthetic interrogation of late-stage phenazine-based metabolite maturation.
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