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Updated: Jan 24, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Influence of Conformational Change and Interligand Hydrogen Bonding in a Chiral Metal-Organic Cage
Shovan Kumar Sen1,2, Ramalingam Natarajan1,2
1Organic and Medicinal Chemistry Division , CSIR - Indian Institute of Chemical Biology , 4, Raja S. C. Mullick Road , Kolkata , 700032 , India.
Abstract:
We report about the coordination-driven self-assembly of a chiral bis-pyridyl ligand (1), synthesized from steroidal cholic acid, with Pd(II) ions to form a chiral metal-organic Pd2(1)4 cage. The self-assembly of the cage was facilitated by favorable conformational change in the alkyl chain of the cholic acid. Interligand hydrogen bonding played a crucial role in directing the formation of a C4 symmetric cage among different possible isomers, as suggested by DFT studies, and control experiments with different ligands.
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