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COtab: Expedient and Safe Setup for Pd-Catalyzed Carbonylation Chemistry
Hugo P Collin1,2, Wallace J Reis1,3, Dennis U Nielsen1
1Department of Chemistry, Interdisciplinary Nanoscience Center (iNANO), Carbon Dioxide Activation Center (CADIAC) , Aarhus University , Gustav Wieds Vej 14 , 8000 Aarhus C , Denmark.
Abstract:
Bench-stable tablets (COtabs) have been developed for the rapid and safe production of carbon monoxide. The tablets can be made in less than 5 min without the use of a glovebox and only require a stock solution of an amine base to liberate a specific quantity of CO in a two-chamber system. The COtabs were tested in five different carbonylation reactions and provided similar yields compared to literature procedures. Finally, a gram-scale reaction was conducted, as well as 13C-isotope labeling of the anticancer drug, olaparib.
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