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Updated: Jan 24, 2026
06:05
Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
Published on: January 27, 2023
27.9K
AKI Associated with Acute Pancreatitis
Tareq I Nassar1, Wajeh Y Qunibi
1Division of Nephrology, Department of Medicine, University of Texas Health at San Antonio, San Antonio, Texas.
Summary
Severe acute pancreatitis frequently leads to acute kidney injury (AKI), a complication with a very poor prognosis and high mortality rates, especially when kidney replacement therapy is needed.
Area of Science:
- Gastroenterology and Nephrology
- Critical Care Medicine
Background:
- Acute pancreatitis is a common cause of hospitalization and in-hospital death.
- Severe acute pancreatitis, affecting 20% of patients, can lead to multiorgan failure.
- Acute kidney injury (AKI) is a frequent, late complication of severe acute pancreatitis with high mortality.
Purpose of the Study:
- To provide an overview of the epidemiology, pathogenesis, causes, and management of AKI in severe acute pancreatitis.
- To highlight the poor prognosis associated with AKI in this patient population.
Main Methods:
- Literature review and synthesis of existing data on AKI in severe acute pancreatitis.
- Analysis of epidemiological trends, pathogenetic mechanisms, and clinical outcomes.
Main Results:
- AKI develops late in severe acute pancreatitis, often after other organ failures.
- Mortality rates for AKI in severe acute pancreatitis exceed 75%, particularly with kidney replacement therapy.
- Pathophysiology involves initial volume depletion and complex vascular/humoral factors.
Conclusions:
- AKI is a significant and often fatal complication of severe acute pancreatitis.
- Understanding the epidemiology, pathogenesis, and management is crucial for improving patient outcomes.
- Further research into the exact pathophysiology is warranted.
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