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Updated: Jan 24, 2026

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
Published on: April 21, 2016
A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect
Hang Chen1, Xiaoqian Zhao1, Zhong Xi1
1Department of General Surgery, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi, Jiangsu Province, People's Republic of China.
Abstract:
Background: A silicon nanowire field effect transistor biosensor has four advantages in the detection of small biomolecules. It is mark-free, immediately responsive, highly sensitive, and specific. However, because of environments with a high salt concentration, the Debye screening effect has been a major issue in biological detection. Objective: To overcome Debye screening effect, realize the clinical application of silicon nanowire field effect transistor and verify its specificity and sensitivity. Materials and methods: The test solution was desalted by miniature blood dialyzer, and then the tumor markers were detected by silicon nanowire field effect transistor. Results: Tumor markers in serum were detected successfully and their sensitivity and specificity were verified. Conclusion: This method was found to effectively promote the development of semiconductor materials in biological solution detection.
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