Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Uterine Tubes01:16

Uterine Tubes

2.2K
The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
2.2K
What is Natural Selection?01:32

What is Natural Selection?

126.4K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
126.4K
Nature and Nurture01:10

Nature and Nurture

22.2K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.2K
Chirality in Nature02:30

Chirality in Nature

16.9K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
16.9K
The Wave Nature of Light02:12

The Wave Nature of Light

61.1K
The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms and was able to demonstrate that white light consists of the individual colors of the rainbow combined together. Newton explained his optics findings in terms of a "corpuscular" view of light, in which light was composed of streams of extremely tiny particles traveling at high speeds according to Newton's laws of motion.
61.1K
Limits to Natural Selection01:38

Limits to Natural Selection

34.2K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
34.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Double negative T cells decline in inflammatory reproductive dysfunction.

Scientific reports·2026
Same author

Unleashing NK cells for cancer immunotherapy in lung cancer: biologic challenges and clinical advances.

Journal of experimental & clinical cancer research : CR·2025
Same author

Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract.

Immunity·2025
Same author

Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus.

Mucosal immunology·2024
Same author

Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1.

Cellular & molecular immunology·2022
Same author

N-Acetyl-L-Cysteine Potentially Inhibits Complement Activation in Transplantation-Associated Thrombotic Microangiopathy.

Transplantation and cellular therapy·2022

Related Experiment Video

Updated: Jan 24, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
10:36

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

7.5K

Uterine Natural Killer Cells.

Dorothy K Sojka1, Liping Yang1, Wayne M Yokoyama1

  • 1Rheumatology Division, Washington University School of Medicine, St. Louis, MO, United States.

Frontiers in Immunology
|May 24, 2019
PubMed
Summary
This summary is machine-generated.

This review explores uterine natural killer (NK) cells during mouse pregnancy. It examines the origins and functions of these important immune cells, highlighting their role in placental development.

Keywords:
conventional natural killer cellsmaternal-fetal interfaceplacentapregnancytissue-resident natural killer cellsuterine innate lymphoid cellsuterine natural killer cells

More Related Videos

Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.4K
Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
09:40

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

2.7K

Related Experiment Videos

Last Updated: Jan 24, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
10:36

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

7.5K
Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.4K
Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
09:40

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

2.7K

Area of Science:

  • Immunology
  • Developmental Biology
  • Cell Biology

Background:

  • Natural killer (NK) cells are a type of innate lymphoid cell (ILC).
  • Tissue-resident NK (trNK) cells, distinct from circulating NK cells, have been identified in various tissues.
  • Uterine NK (uNK) cells are abundant during pregnancy and crucial for placental development.

Purpose of the Study:

  • To review the origins and functions of heterogeneous uterine NK cell populations during murine pregnancy.
  • To address challenges in studying uNK cells due to the dynamic pregnant uterus microenvironment.
  • To investigate the contribution of tissue-resident NK cells to uterine NK cells during pregnancy.

Main Methods:

  • Literature review focusing on murine pregnancy models.
  • Analysis of studies on innate lymphoid cells and NK cell subsets.
  • Examination of research on placental vascular remodeling and immune cell interactions.

Main Results:

  • The murine uterus contains predominantly trNK cells in non-pregnant states.
  • Prior studies suggested uNK cells are mainly derived from circulating NK cells.
  • The precise origins and functions of uNK cells in pregnancy remain complex and require further investigation.

Conclusions:

  • Uterine NK cells are a heterogeneous population with diverse origins and functions during pregnancy.
  • Understanding uNK cell heterogeneity is critical for comprehending maternal-fetal interactions.
  • Further research is needed to elucidate the full role of trNK cells and other uNK cell subsets in successful pregnancy.