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Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210

Xuelian Chen1, Lanying Ma2, Xi Wang1

  • 1State Key Laboratory of Molecular Oncology and Department of Medical Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College-Medical Oncology, Beijing 100021, China.

Cancer Biology & Medicine
|May 24, 2019
PubMed
Abstract

Insights

Reactive capillary hemangiomas (RCHs) are common skin toxicities in patients receiving SHR-1210, an anti-PD-1 agent. These manageable RCHs were associated with positive tumor response in this phase I study.

Area of Science:

  • Oncology
  • Immunology
  • Dermatology

Background:

  • SHR-1210 is a novel anti-programmed cell death protein 1 (PD-1) agent investigated for solid tumors.
  • Immune-related adverse events (irAEs) are common with PD-1 inhibitors.
  • A novel dermatologic toxicity, reactive capillary hemangiomas (RCHs), was observed during SHR-1210 therapy.

Purpose of the Study:

  • To summarize the clinical features of RCHs.
  • To assess the prevalence and management of RCHs during SHR-1210 treatment.
  • To investigate the association between RCHs and tumor response.

Main Methods:

  • Prospective observational study of 98 patients with advanced solid tumors receiving SHR-1210.
  • Systematic skin inspections every two weeks.
  • Recording of RCHs' clinical course and association with objective tumor response.

Main Results:

  • RCHs occurred in 85.7% of patients, mostly as grade 1 adverse events.
  • RCH onset was dose-dependent, with earlier onset at 400 mg.
  • Tumor objective response rate was 28.9% in patients with RCHs versus 0% in those without.

Conclusions:

  • Reactive capillary hemangiomas are prevalent but manageable dermatologic toxicities associated with SHR-1210.
  • RCHs may serve as a potential biomarker for anti-tumor response to SHR-1210.
  • Further research into immune-related dermatologic adverse events is warranted.
Keywords:
Reactive capillary hemangiomasSHR-1210anti-tumor efficacyskin toxicity

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