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Related Concept Videos

Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Chronic Kidney Disease I: Introduction01:25

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Obstructive Pulmonary Disease-I: Introduction01:20

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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
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Chronic Obstructive Pulmonary Disease-V: Management01:29

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Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Updated: Jan 24, 2026

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
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Mitochondrial dysfunction and chronic lung disease.

Tingting Fang1, Manni Wang1, Hengyi Xiao2

  • 1Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and National Collaborative Innovation Center, Chengdu, 610041, China.

Cell Biology and Toxicology
|May 24, 2019
PubMed
Summary
This summary is machine-generated.

Mitochondrial dysfunction is a key aging marker and disease trigger in the lungs. Targeting mitochondria may offer new treatments for age-related lung diseases like COPD and idiopathic pulmonary fibrosis.

Keywords:
Chronic lung diseasesMitochondrial dynamicMitochondrial dysfunctionmtDNAmtROS

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Area of Science:

  • Gerontology and Respiratory Medicine
  • Cellular Aging and Disease Mechanisms

Background:

  • Bodily functions decline with age, increasing susceptibility to age-related diseases.
  • Respiratory diseases linked to aging include COPD, IPF, asthma, and lung cancer.
  • Mitochondrial dysfunction is both a hallmark and a trigger of aging and disease.

Purpose of the Study:

  • To elucidate mitochondrial dysfunction as a marker of aging in the lung.
  • To explore the role of mitochondrial dysfunction in age-related lung diseases.
  • To investigate mitochondria as a potential therapeutic target for lung aging diseases.

Main Methods:

  • Review of current literature on aging, mitochondrial function, and lung diseases.
  • Analysis of the relationship between mitochondrial dysfunction and specific age-related respiratory conditions.
  • Discussion of therapeutic strategies targeting mitochondrial pathways in lung aging.

Main Results:

  • Mitochondrial dysfunction is consistently observed in aging lungs.
  • This dysfunction contributes to the pathogenesis of various age-related lung diseases.
  • Evidence suggests mitochondria play a critical role in the aging lung disease process.

Conclusions:

  • Mitochondrial dysfunction is a significant aging marker in the respiratory system.
  • Targeting mitochondrial health presents a promising avenue for treating lung diseases of aging.
  • Further research into mitochondrial-based therapies is warranted for respiratory aging.