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A Natural Mouse Model for Neisseria Persistent Colonization.

Katherine Rhodes1, Mancheong Ma1, Magdalene So2

  • 1Department of Immunobiology, BIO5 Institute, University of Arizona, Tucson, AZ, USA.

Methods in Molecular Biology (Clifton, N.J.)
|May 24, 2019
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Summary

A new mouse model uses Neisseria musculi to study asymptomatic Neisseria colonization. This system allows researchers to investigate host-pathogen interactions and develop vaccines for persistent bacterial infections.

Keywords:
Colonization and persistenceCommensal NeisseriaMouse modelPathogenic Neisseria

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Area of Science:

  • Microbiology
  • Immunology
  • Genetics

Background:

  • Commensal Neisseria species are important in host-microbe interactions but challenging to study in vivo.
  • Previous models faced host restriction barriers, limiting research into Neisseria's behavior within a living organism.

Purpose of the Study:

  • To develop a natural mouse model for studying persistent colonization by commensal Neisseria.
  • To enable the dissection of host and bacterial factors contributing to asymptomatic colonization.
  • To provide a platform for investigating the in vivo function of shared Neisseria genes and for vaccine development.

Main Methods:

  • Coupling laboratory mice with Neisseria musculi (Nmus), a commensal bacterium found in wild mice.
  • Utilizing noninvasive inoculation procedures.
  • Observing bacterial burdens in colonized mice for up to one year post-inoculation.

Main Results:

  • The Nmus-mouse model circumvents host restriction barriers, allowing for in vivo study of Neisseria.
  • Asymptomatic colonization by Nmus is achievable and can persist for up to one year.
  • Susceptibility to Nmus colonization demonstrates variation based on host genetic background.

Conclusions:

  • This natural mouse model offers a novel system for studying persistent Neisseria colonization and host-microbe interactions.
  • The model facilitates research into the in vivo roles of Neisseria host interaction factors and potential vaccine targets.
  • The genetic tractability of Nmus enhances its utility for future research and therapeutic development.