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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Proteomic Approaches to Decipher Mechanisms Underlying Pathogenesis in Multiple Sclerosis Patients
Vaibhav Singh1, Ajai Tripathi1, Ranjan Dutta1
1Department of Neurosciences, Cleveland Clinic, Cleveland, OH, 44195, USA.
Proteomics
|May 24, 2019
Summary
Proteomics offers a powerful approach to identify biomarkers for multiple sclerosis (MS), a central nervous system (CNS) disease. This review explores how proteomic analysis of CNS tissues and biofluids advances understanding of MS pathogenesis and aids therapeutic development.
Area of Science:
- Neuroimmunology
- Proteomics
- Biomarker Discovery
Background:
- Multiple sclerosis (MS) is a chronic, progressive CNS disease with unknown etiology.
- Current therapies do not halt neurological disability, necessitating better understanding of pathogenesis.
- Biomarkers are crucial for identifying MS pathophysiology and monitoring disease progression.
Purpose of the Study:
- To review the application of proteomic technologies in multiple sclerosis research.
- To highlight proteomic insights into MS pathogenesis, particularly during disease progression.
- To discuss current challenges and future directions for proteomic approaches in MS.
Main Methods:
- Proteomic analysis of central nervous system (CNS) tissues from MS patients.
- Proteomic analysis of biofluids (e.g., cerebrospinal fluid, blood) from MS patients.
- Review of existing literature on proteomic findings in MS.
Main Results:
- Proteomics has provided significant clues into the complex pathogenesis of MS.
- Identification of potential biomarkers for MS pathophysiology and progression.
- Demonstration of proteomics as a key tool for accelerating biomarker discovery.
Conclusions:
- Proteomic strategies are vital for unraveling MS pathogenesis and developing effective therapies.
- Further research using advanced proteomic techniques is needed to fully understand MS.
- Biomarker discovery through proteomics holds promise for improved MS management.
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