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Updated: Jan 24, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
[Optimization of surgical care for the hemorrhagic colorectal cancer]
A V Shabunin1, Z A Bagateliya1, I Yu Korzheva1
1Botkin Municipal Clinical Hospital, Moscow, Russian Federation; Chair of Surgery of the Russian Medical Academy of Continuing Postgraduate Education of Healthcare Ministry of the Russian Federation, Moscow, Russian Federation.
Aim:
To optimize surgical care for the hemorrhagic colorectal cancer.
Material And Methods:
77 patients diagnosed with hemorrhagic colorectal cancer were reviewed: 9 patients of them were efficaciously treated with conservative therapy (I group); 47 - underwent successful endoscopic coagulation (I); 4 - arterial embolization (I), 2 - ligation of internal iliac arteries (I), 15 - acute resection (II group). 20 of 62 patients I group underwent plan surgery and radiation or chemotherapy during 7-10 days after hemostasis and normalization hemoglobin. The 3-year cumulative survival after resections (acute versus plan) was plotted on a Kaplan-Meier chart in 31 patients.
Results:
Complications and postoperative mortality was significantly higher after acute resection (II group) compared with plan resection (I): 33,3% vs 20%; 15% vs 5%, respectively. The survival rate was higher after plan than acute resections: 0,8882 and 0,3571, respectively.
Conclusion:
Acute surgery for hemorrhagic colorectal cancer should only be carried out by appropriately trained surgeons in multi-specialty hospital. Endoscopy and arterial embolization are the most effective means of successfully controlling hemorrhage while minimizing potential complications. A bridging strategy may be a valid alternative in some of patients with hemorrhagic colorectal cancer, because a significantly lower postoperative mortality rate.
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