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Salidroside inhibits migration and invasion of poorly differentiated thyroid cancer cells

Hongxia Shang1, Shengnan Wang2, Jinming Yao1

  • 1Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.

Thoracic Cancer
|May 24, 2019
PubMed
Abstract

Insights

Salidroside effectively inhibits the migration and invasion of poorly differentiated thyroid cancer cells. This natural compound also promotes cancer cell death by targeting the JAK2-STAT3 signaling pathway.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Poorly differentiated thyroid cancer lacks effective treatments, particularly when resistant to radioiodine and exhibiting metastasis.
  • Salidroside demonstrates anticancer properties, yet its specific effects on thyroid cancer remain uninvestigated.

Purpose of the Study:

  • To investigate the impact of salidroside on the migration and invasion capabilities of poorly differentiated thyroid cancer cells.

Main Methods:

  • Utilized wound-healing and transwell assays to assess migration and invasion in WRO cells.
  • Quantified MMP2 and MMP9 expression via qRT-PCR and Western blot.
  • Analyzed JAK2/STAT3 phosphorylation and apoptosis-related proteins (Bax, cleaved caspase 3, Bcl-2) using Western blot.

Main Results:

  • Salidroside significantly reduced migration and invasion in WRO cells while inducing apoptosis.
  • Inhibited mRNA and protein expression of MMP2 and MMP9.
  • Suppressed JAK2/STAT3 phosphorylation and modulated apoptosis-related protein levels.

Conclusions:

  • Salidroside demonstrates significant potential in inhibiting thyroid cancer cell migration and invasion.
  • The mechanism involves the suppression of the JAK2-STAT3 signaling pathway.
Keywords:
Invasionmigrationpoorly differentiated thyroid cancersalidroside

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