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Methanol Independent Expression by Pichia Pastoris Employing De-repression Technologies
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HoxA9 binds and represses the Cebpa +8 kb enhancer.

Lei Peng1, Hong Guo1, Peilin Ma2

  • 1Division of Pediatric Oncology, Johns Hopkins University, Baltimore, Maryland, United States of America.

Plos One
|May 24, 2019
PubMed
Summary

HoxA9 directly represses Cebpa gene expression, particularly through the +8 kb enhancer. This repression may maintain myeloid progenitor immaturity and contribute to acute myeloid leukemia development.

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