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Updated: Jan 24, 2026

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
Published on: February 11, 2017
Swelling Gliotransmission by SWELL1 Channels
Paulo Kofuji1, Alfonso Araque1
1Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Abstract:
Astrocytes release glutamate, which can modulate nearby synapses, but how this release is accomplished remains debated. In this issue of Neuron, Yang et al. (2019) show that the volume-regulated anion channel Swell1 in astrocytes mediates the release of glutamate and impacts synaptic transmission, learning and memory, and neurotoxicity.
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