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Molecular imaging and therapy of somatostatin receptor positive tumors

Jana Ivanidze1, Michelle Roytman1, Arielle Sasson2

  • 1New York-Presbyterian Hospital/Weill Cornell Medical Center, United States of America.

Clinical Imaging
|May 24, 2019
PubMed

Insights

Gallium-68 DOTATATE PET imaging targets somatostatin receptors (SSTR) in neuroendocrine neoplasms. This method offers superior diagnostic attributes compared to older imaging agents, enabling better patient care and potential therapeutic applications.

Area of Science:

  • Molecular imaging
  • Nuclear medicine
  • Oncology

Background:

  • Somatostatin receptors (SSTR) are frequently overexpressed in neuroendocrine neoplasms.
  • SSTR-targeted molecular imaging is crucial for diagnosing and managing these tumors.

Purpose of the Study:

  • To review the current advancements in SSTR-targeted molecular imaging.
  • To discuss the diagnostic and therapeutic potential of these imaging techniques.

Main Methods:

  • Positron Emission Tomography (PET) imaging using 68Ga-DOTATATE.
  • Targeting of Somatostatin Receptor subtype 2A (SSTR2A), commonly overexpressed in neuroendocrine tumors.
  • Comparison with older imaging agents like 111In-pentetreotide.

Main Results:

  • 68Ga-DOTATATE demonstrates superior imaging attributes, including specific SSTR2 targeting.
  • Advantages include lower radiation dose, shorter study duration, quantifiable uptake, and reduced cost.
  • 68Ga-DOTATATE shows improved performance over 111In-pentetreotide for neuroendocrine tumor imaging.

Conclusions:

  • 68Ga-DOTATATE PET imaging represents a significant advancement in SSTR-targeted molecular imaging.
  • Optimal patient care requires dedicated training and staying updated with scientific literature.
  • Ongoing research explores further diagnostic and therapeutic applications in neuroendocrine neoplasms.
Keywords:
(68)Ga-DOTATATE PET/CTNeuroendocrine tumorsSomatostatin receptors

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