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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
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TRP Channels as Lower Urinary Tract Sensory Targets
1Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA. karl-erik.andersson@med.lu.se.
Medical Sciences (Basel, Switzerland)
|May 25, 2019
Summary
Transient Receptor Potential (TRP) channels in the lower urinary tract are key for bladder function and pain. Further research into TRP channel modulators may offer new treatments for bladder disorders.
Area of Science:
- Urology
- Neuroscience
- Molecular Biology
Background:
- Transient Receptor Potential (TRP) channels are expressed throughout the lower urinary tract (LUT), including neuronal and smooth muscle tissues.
- These channels, such as TRPV1-4, TRPM4, TRPM8, and TRPA1, play roles in pain signaling and mechanotransduction within the LUT.
Purpose of the Study:
- To review the expression and function of TRP channels in the lower urinary tract.
- To explore the potential of TRP channel modulators for treating bladder dysfunction and pain disorders.
Main Methods:
- Review of existing animal studies and scientific literature on TRP channel expression and function in the lower urinary tract.
- Analysis of the translational gap between animal findings and clinical applications.
Main Results:
- TRP channels are integral to normal human bladder function and are implicated in various pathological conditions.
- Animal studies suggest therapeutic potential for TRP channel modulators in bladder over/underactivity and pain.
Conclusions:
- TRP channels are crucial for lower urinary tract sensory functions and hold therapeutic promise.
- Development of selective TRP channel agonists and antagonists is essential for advancing clinical applications and understanding physiological roles.
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