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Sinerga may prevent recurrent respiratory infections in allergic children

F Ameli1, G Ciprandi2

  • 1Otorhinolaryngology Unit, Villa Montallegro, Genoa, Italy.

Journal of Biological Regulators and Homeostatic Agents
|May 25, 2019
PubMed

Insights

This study shows that Sinerga, a dietary supplement, significantly reduced recurrent respiratory infections (RRI) in allergic children. Supplementation also decreased turbinate size, suggesting a role in managing allergic inflammation.

Area of Science:

  • Immunology
  • Otolaryngology
  • Pediatrics

Background:

  • Recurrent respiratory infections (RRI) pose a significant clinical challenge, particularly in allergic children.
  • Modulating the immune system is a potential strategy for preventing RRI.

Discussion:

  • Sinerga, a supplement containing palmitoylethanolamide (PEA), Kluyveromyces marxianus B0399, bovine colostrum, and phenylalanine, was investigated.
  • The study compared Sinerga plus standard therapy (antihistamine and intranasal corticosteroid) against standard therapy alone in allergic children with RRI.

Key Insights:

  • Sinerga supplementation significantly reduced the incidence of respiratory infections in allergic children.
  • A notable reduction in the size of inferior and middle turbinates was observed in the Sinerga group.
  • These findings align with the proposed immune-modulating mechanisms of Sinerga's components.

Outlook:

  • Sinerga demonstrates potential as an adjunct therapy for preventing RRI in allergic pediatric populations.
  • Further research could explore the specific contributions of each Sinerga component to immune modulation and symptom reduction.

Keywords:
Sinergaallergychildrenimmune systemmast cellrecurrent respiratory infection

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