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IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance

Taichi Muraguchi1, Daisuke Nanba2, Emi K Nishimura2

  • 1Bioscience & Technology Development Center, FUJIFILM Corporation, 577 Kaisei, Kanagawa 258-8577, Japan; Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Journal of Dermatological Science
|May 25, 2019
PubMed
Abstract

Keywords:
CRISPR-Cas9Human skin equivalentIGF-1/IGF-1R signalingKeratinocyte

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