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Updated: Jan 24, 2026
09:24
3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
9.5K
Radiotherapy Management of Muscle Invasive Bladder Cancer: Evaluation of a National Cohort
M Varughese1, S Treece2, K J Drinkwater3
1Taunton and Somerset NHS Foundation Trust, Taunton, UK.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|May 25, 2019
Summary
This study benchmarks UK bladder cancer radiotherapy, finding delays in treatment initiation and suboptimal use of neoadjuvant chemotherapy and chemoradiotherapy. Improvements are needed to streamline patient pathways and enhance care quality for muscle-invasive bladder cancer (MIBC).
Area of Science:
- Oncology
- Radiotherapy
- Urologic Oncology
Background:
- Outcomes for muscle-invasive bladder cancer (MIBC) have stagnated over 30 years.
- Contemporary UK radiotherapy practice for MIBC requires benchmarking against national guidelines.
Purpose of the Study:
- To benchmark current UK radiotherapy practices for muscle-invasive bladder cancer (MIBC).
- To identify areas for improvement in MIBC management and radiotherapy delivery.
Main Methods:
- A prospective, multicentre study involving 59 UK radiotherapy centres.
- Questionnaires were completed for 508 patients with MIBC undergoing radiotherapy from December 2016 over 16 weeks.
Main Results:
- 41 centres (69%) participated, detailing 508 patients (median age 78).
- Significant delays were observed: 57 days to neoadjuvant chemotherapy (NAC) and 82 days to radical radiotherapy.
- NAC was used in 43% and concurrent chemoradiotherapy (CRT) in 40% of radical cases, with suboptimal uptake.
Conclusions:
- This is the largest prospective UK study on MIBC radiotherapy, characterizing an elderly population.
- Urgent streamlining of treatment pathways is needed due to treatment delays.
- Increased use of NAC is noted, but CRT penetration is low, highlighting areas for practice improvement and future trial design.
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