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Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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Death by antibody.

Timothy Faccini1, Zaneeta Dhesi1, Sachin Shah1

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Summary
This summary is machine-generated.

Patients on anti-interleukin 17A therapy and extracorporeal membrane oxygenation (ECMO) face increased Candida infection risk. Early fungal screening is vital for critically ill patients on these treatments.

Keywords:
adult intensive carebiological agentsdrugs: musculoskeletal and joint diseasesinfectious diseases

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • A patient with psoriatic arthritis on anti-interleukin 17A (anti-IL-17A) therapy developed sepsis-induced cardiomyopathy.
  • The patient required veno-arterial extracorporeal membrane oxygenation (ECMO) for critical cardiovascular support.

Observation:

  • Following ECMO, the patient developed invasive candidemia with intra-abdominal fungal collections.
  • Despite antifungal treatment and drainage attempts, the patient's condition was fatal.

Findings:

  • Both anti-IL-17A therapy and ECMO are identified as significant independent risk factors for Candida infections.
  • This case highlights a severe complication in a patient with combined risk factors.

Implications:

  • Increased use of monoclonal antibody therapies and ECMO necessitates heightened awareness of fungal infection risks.
  • Early screening and prompt initiation of antifungal treatment are crucial for improving outcomes in critically ill patients with these risk factors.