Pfeifer-Weber-Christian disease and successful treatment with mycophenolate mofetil: a case report

Area of Science:

• Internal Medicine
• Dermatology
• Nephrology

Background:

• Panniculitis is an inflammatory condition affecting subcutaneous fat, presenting as tender, erythematous nodules.
• Historically documented since the late 19th century, panniculitis can involve systemic inflammatory responses.
• Recurrent cases may present with significant systemic complications.

Observation:

• A Caucasian man experienced recurrent febrile illness and systemic inflammation.
• The patient developed renal dysfunction requiring intensive care.
• This presentation was consistent with a severe, systemic form of panniculitis.

Findings:

• The patient's recurrent episodes and systemic inflammatory response were successfully managed.
• Treatment with the antiproliferative agent mycophenolate mofetil proved effective.
• Mycophenolate mofetil prevented subsequent episodes of febrile illness and renal dysfunction.

Implications:

• Antiproliferative agents like mycophenolate mofetil can be a viable treatment option for severe panniculitis.
• Early intervention with immunosuppressive therapy may prevent severe systemic complications, including renal dysfunction.
• This case highlights the importance of considering systemic inflammatory conditions in patients with recurrent fevers and organ dysfunction.