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Updated: Jan 24, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

14.9K

Pazopanib in advanced soft tissue sarcomas

Alex T J Lee1,2, Robin L Jones2,3, Paul H Huang1

  • 11Division of Molecular Pathology, The Institute of Cancer Research, London, UK.

Signal Transduction and Targeted Therapy
|May 25, 2019
PubMed

Insights

Pazopanib improves progression-free survival in patients with advanced soft tissue sarcoma (STS). This review summarizes pazopanib

Area of Science:

  • Oncology
  • Pharmacology
  • Medical Research

Background:

  • Pazopanib is a tyrosine kinase inhibitor approved for soft tissue sarcoma (STS).
  • It targets vascular endothelial growth factor receptors, inhibiting angiogenic and oncogenic pathways.
  • Pazopanib is also approved for advanced renal cell carcinoma.

Purpose of the Study:

  • To review preclinical and clinical data for pazopanib in STS.
  • To outline the evidence for pazopanib's efficacy in various STS subtypes.
  • To explore potential biomarkers for pazopanib therapy in advanced STS.

Main Methods:

  • Review of preclinical studies on pazopanib's mechanism of action.
  • Analysis of Phase III randomized trial data for pazopanib in STS.
  • Examination of real-world case series on pazopanib's efficacy in STS cohorts.

Main Results:

  • Pazopanib demonstrated improved progression-free survival versus placebo in pretreated STS patients.
  • Efficacy has been described in mixed and subtype-specific STS cohorts.
  • No validated predictive biomarkers currently exist for selecting patients for pazopanib therapy.

Conclusions:

  • Pazopanib is an effective treatment for advanced STS across multiple subtypes.
  • Lack of predictive biomarkers limits optimal patient selection and cost-effectiveness.
  • Further research into biomarkers is needed to enhance pazopanib's clinical utility.
Keywords:
Cancer therapySarcoma

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