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Related Concept Videos

Correlations02:20

Correlations

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Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
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Habitat Fragmentation02:31

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Habitat fragmentation describes the division of a more extensive, continuous habitat into smaller, discontinuous areas. Human activities such as land conversion, as well as slower geological processes leading to changes in the physical environment, are the two leading causes of habitat fragmentation. The fragmentation process typically follows the same steps: perforation, dissection, fragmentation, shrinkage, and attrition.
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Correlation and Causation01:27

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Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
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Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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Correlation01:09

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In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
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Thermal Strain01:19

Thermal Strain

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Thermal strain is a concept that arises when we consider how temperature changes affect structures. Unlike the conventional assumption that structures remain constant under load, real-world scenarios often involve temperature fluctuations that can significantly impact these structures. Consider a homogeneous rod with a uniform cross-section resting freely on a flat horizontal surface. If the rod's temperature increases, the rod elongates. This elongation is proportional to the temperature...
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Related Experiment Video

Updated: Jan 24, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
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Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

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Aortic Strain Correlates with Elastin Fragmentation in Fibrillin-1 Hypomorphic Mice.

Jeff Z Chen1,2, Hisashi Sawada1, Jessica J Moorleghen1

  • 1Saha Cardiovascular Research Center.

Circulation Reports
|May 25, 2019
PubMed
Summary

Fibrillin-1 mutations in mice lead to increased aortic diameter and reduced aortic strain due to elastin fragmentation. This fragmentation is directly linked to diminished aortic function in these models.

Keywords:
Marfan syndromecircumferential strainelastin fragmentationthoracic aortic aneurysmultrasound

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Related Experiment Videos

Last Updated: Jan 24, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
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Intermediate Strain Rate Material Characterization with Digital Image Correlation
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Area of Science:

  • Cardiovascular Biology
  • Biomechanical Engineering
  • Genetics

Background:

  • High-frequency ultrasound enables in vivo measurement of murine ascending aortas and calculation of aortic strain.
  • Thoracic aortic aneurysms linked to fibrillin-1 (FBN1) mutations exhibit elastin fragmentation, potentially affecting aortic strain.

Purpose of the Study:

  • To determine the relationship between elastin fragmentation and aortic circumferential strain in wild-type and FBN1 hypomorphic (FBN1mgR/mgR) mice.

Main Methods:

  • In vivo measurement of ascending aortic diameters in systole and diastole using high-frequency ultrasound.
  • Quantification of aortic circumferential strain in wild-type and FBN1mgR/mgR mice.
  • Assessment of elastin fragmentation and its correlation with aortic strain and diameter.

Main Results:

  • FBN1mgR/mgR mice exhibited significantly reduced aortic expansion (4.5-4.9%) compared to wild-type mice (16.3-17.0%).
  • Reduced circumferential strain was observed in FBN1mgR/mgR mice.
  • Elastin fragmentation was inversely correlated with circumferential strain (R^2=0.628, p=0.004) and correlated with aortic diameter.

Conclusions:

  • FBN1mgR/mgR mice display increased aortic diameters, reduced circumferential strain, and elevated elastin fragmentation.
  • Elastin fragmentation is a key factor associated with reduced aortic circumferential strain in both FBN1 mutant and wild-type mice.