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Updated: Jan 24, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
[Growing prostheses after sarcoma resection in children and adolescents]
R Windhager1, P Funovics2, J Panotopoulos2
1Universitätsklinik für Orthopädie und Unfallchirurgie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich. reinhard.windhager@meduniwien.ac.at.
Growing prostheses offer a limb-sparing alternative for pediatric sarcomas. However, high complication rates, particularly infections and mechanical failures, necessitate thorough discussion with patients and families.
Area of Science:
- Pediatric Orthopedics
- Surgical Oncology
- Biomedical Engineering
Background:
- Growing prostheses are a valuable alternative to amputation and rotationplasty for treating childhood bone and soft-tissue sarcomas.
- Technological advancements have led to improved invasive and non-invasive extendable prosthesis designs over the past three decades.
Purpose of the Study:
- To review the current literature on growing prostheses for pediatric sarcomas.
- To evaluate the efficacy and complication rates of these devices.
Main Methods:
- Systematic review of 21 peer-reviewed publications.
- Analysis of data from 590 patients fitted with growing prostheses.
- Assessment of functional outcomes and complication rates.
Main Results:
- Satisfactory functional results were reported (78.3/100 MSTS points).
- High complication rates were observed: 27.3% infections and 22.4% mechanical failures.
- Infection risk increases with longer follow-up periods.
Conclusions:
- Growing prostheses provide a limb-sparing option for pediatric sarcomas.
- The significant risk of complications, especially infections, is a major drawback.
- Informed consent discussions with patients and parents are crucial regarding these risks.
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