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Altered regional homogeneity in pediatric bipolar disorder during manic and euthymic state: a resting-state fMRI

Qian Xiao1, Dong Cui2, Qing Jiao2

  • 1Mental Health Centre of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Brain Imaging and Behavior
|May 25, 2019
PubMed

Insights

Resting-state fMRI reveals distinct brain activity patterns in pediatric bipolar disorder (PBD). Manic PBD patients show altered brain signals in key regions compared to euthymic patients and controls.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Pediatric bipolar disorder (PBD) is a severe mental illness with episodes of mania and depression.
  • Understanding neurobiological differences between manic and euthymic states in PBD is crucial.

Purpose of the Study:

  • To investigate resting-state brain activity abnormalities in pediatric bipolar disorder (PBD) using functional magnetic resonance imaging (fMRI).
  • To compare brain activity patterns between manic PBD patients, euthymic PBD patients, and healthy controls.

Main Methods:

  • Resting-state fMRI was employed to measure regional homogeneity (ReHo) in 22 manic PBD patients, 21 euthymic PBD patients, and 19 healthy controls.
  • Analysis focused on identifying differences in cortical and subcortical ReHo signals across the three groups.

Main Results:

  • Manic PBD patients exhibited reduced cortical ReHo in the superior temporal gyrus (STG) and superior parietal lobe (SPL), and altered subcortical ReHo in the insula and cerebellum crus I compared to controls.
  • Euthymic PBD patients showed reduced cortical ReHo in the STG and SPL compared to controls.
  • Significant differences in ReHo signals were observed between manic and euthymic PBD patients in the insula, cerebellum crus I, and STG.

Conclusions:

  • Altered ReHo signals in PBD involve cortical-limbic systems critical for emotional and cognitive processing.
  • Distinct neurobiological differences exist between manic and euthymic states in pediatric bipolar disorder, particularly in the insula, cerebellum crus I, and STG.

Keywords:
Euthymic stateManic statePediatric bipolar disorderRegional homogeneityResting-state fMRI

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