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Staphylococcus aureus antibiotic susceptibility patterns in pediatric atopic dermatitis
Cristopher C Briscoe1, Patrick Reich2, Stephanie Fritz2
1Washington University School of Medicine, St. Louis, Missouri.
Pediatric Dermatology
|May 25, 2019
Summary
Methicillin-sensitive Staphylococcus aureus (MSSA) is common in pediatric atopic dermatitis (AD) patients. For those with prior MRSA infections, doxycycline or TMP-SMX may be considered.
Area of Science:
- Dermatology
- Infectious Diseases
- Pediatrics
Background:
- Staphylococcus aureus is a prevalent pathogen in pediatric atopic dermatitis (AD) patients with skin infections.
- Limited guidance exists for empiric antibiotic selection in this population.
Purpose of the Study:
- To characterize S. aureus strains from pediatric AD patients with skin infections.
- To assess factors associated with methicillin resistance.
- To compare S. aureus susceptibility patterns in AD patients versus emergency department patients.
Main Methods:
- Retrospective study of pediatric AD patients over five years.
- Analysis of patient demographics and bleach bath usage.
- Comparison of S. aureus culture results with a control group from emergency department visits.
Main Results:
- Methicillin-sensitive S. aureus (MSSA) was more prevalent (77.8%) than methicillin-resistant S. aureus (MRSA) (22.2%).
- No correlation found between MRSA and age, sex, race, or bleach bath use.
- AD patients showed lower MSSA susceptibility to doxycycline and MRSA susceptibility to TMP-SMX compared to the control group.
Conclusions:
- First-generation cephalosporins are appropriate empiric therapy for most pediatric AD patients.
- Consider empiric doxycycline or TMP-SMX for patients with a history of MRSA due to high susceptibility rates.
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