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Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
Published on: October 27, 2023
Association study between matrix metalloproteinase-3 gene (MMP3) polymorphisms and ankylosing spondylitis
Yong Zhu1, Shunan Li2, Zhi Huang1
1The Second Affiliated Hospital of Inner, Mongolia Medical University, Hohhot, China.
Background:
Ankylosing spondylitis (AS) is the second most common cause of inflammatory arthritis worldwide affecting the axial skeleton. Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase-3 (MMP3) in the development of AS has few been investigated in Chinese population.
Methods:
A total of 362 patients with AS and 362 healthy controls were enrolled in the study. Five SNPs in MMP3 genotypes were identified by Agena MassARRAY. Chi-squared tests and genetic model were used to evaluate associations.
Results:
rs522616 had a significant risk of AS development compared to those with the TT genotype (p = 0.008). By multiple logistic regression models analysis, in codominant model, rs522616 CT genotypes also had a 1.44-fold risk (95% CI = 1.06-1.96, p = 0.008) for AS development compared to those with TT genotypes. In recessive model, the CC genotypes was a significantly reduced AS risk for individuals with TT/CT genotype (OR = 0.64; 95% CI = 0.41-0.99, p = 0.040).
Conclusion:
The present study suggests that MMP3 rs522616 polymorphism is associated with AS susceptibility and MMP3 might be a potential diagnostic biomarker for AS. Further independent studies with larger cohorts are warranted to validate our findings in different populations.
Insights
The matrix metalloproteinase-3 (MMP3) rs522616 gene variant increases the risk of developing ankylosing spondylitis (AS). This MMP3 polymorphism may serve as a diagnostic biomarker for AS.
Area of Science:
- Genetics
- Immunology
- Rheumatology
Background:
- Ankylosing spondylitis (AS) is a prevalent axial skeleton inflammatory arthritis.
- The role of matrix metalloproteinase-3 (MMP3) single nucleotide polymorphisms (SNPs) in AS development requires further investigation, particularly in Chinese populations.
Purpose of the Study:
- To investigate the association between MMP3 gene polymorphisms and ankylosing spondylitis susceptibility in a Chinese cohort.
- To explore the potential of MMP3 as a diagnostic biomarker for AS.
Main Methods:
- A case-control study involving 362 AS patients and 362 healthy controls.
- Genotyping of five MMP3 SNPs using Agena MassARRAY.
- Statistical analysis including Chi-squared tests and genetic models to assess genotype-AS associations.
Main Results:
- The MMP3 rs522616 polymorphism was significantly associated with AS risk.
- Specifically, rs522616 CT genotypes showed a 1.44-fold increased risk (codominant model, p=0.008).
- CC genotypes demonstrated a reduced AS risk (recessive model, OR=0.64, p=0.040).
Conclusions:
- MMP3 rs522616 polymorphism is linked to ankylosing spondylitis susceptibility.
- MMP3 may represent a potential diagnostic biomarker for AS.
- Further validation in larger, diverse cohorts is recommended.
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