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Factors Associated with Adherence to Allergen Specific Subcutaneous Immunotherapy
Ji Ho Lee1, So Hee Lee2, Ga Young Ban3
1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Yonsei Medical Journal
|May 25, 2019
Summary
Allergen-specific immunotherapy (AIT) adherence is crucial for long-term benefits. Younger patients, specific build-up schedules, and fewer hospital visits are linked to non-adherence in AIT for allergic diseases.
Area of Science:
- Allergy and Immunology
- Clinical Practice
- Patient Adherence Research
Background:
- Allergen-specific immunotherapy (AIT) is the only treatment that can modify the natural course of allergic diseases.
- Long-term efficacy, requiring at least 3 years of treatment, is essential for sustained disease modification.
Purpose of the Study:
- To investigate factors influencing immunotherapy non-adherence in real-world clinical practice.
- To identify patient and treatment characteristics associated with failing to complete 3 years of AIT.
Main Methods:
- Retrospective review of medical records for patients with allergic rhinitis, asthma, or atopic dermatitis receiving AIT.
- Definition of non-adherence as failure to complete the recommended 3-year AIT duration.
Main Results:
- 19.6% of 1162 patients did not complete 3 years of AIT.
- Younger age (under 40), cluster or ultra-rush build-up schedules, and fewer visits to other hospital departments were associated with non-adherence.
- Longer disease duration (5-10 years) showed a negative association with non-adherence.
Conclusions:
- Multiple factors impact adherence to AIT, affecting its overall utility.
- Clinicians must recognize these adherence factors to optimize the effectiveness of allergen-specific immunotherapy.
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