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Related Experiment Video

Updated: Jan 24, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

[Preimplantation genetic testing for aneuploidy].

Viktoria Holmqvist¹, Laura Kristine Soenderberg Roos, Kristin Ros Kjartansdottir

¹Viktoria.holmqvist@hotmail.com.

Ugeskrift for Laeger

|May 25, 2019

Summary

This summary is machine-generated.

Preimplantation genetic testing for aneuploidy (PGT-A) has evolved, but its effectiveness in improving live birth rates remains debated. Current methods focus on blastocyst biopsies, yet outcomes are still under scrutiny for clinical benefit and cost-effectiveness.

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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

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Published on: August 25, 2019

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FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Area of Science:

Reproductive Medicine
Genetics
Embryology

Background:

Preimplantation genetic testing for aneuploidy (PGT-A) aims to enhance live birth rates (LBR) by selecting euploid embryos.
Early PGT-A methods using fluorescence in situ hybridisation (FISH) on cleavage stage embryos in the 2000s yielded disappointing results, showing reduced LBR.

Purpose of the Study:

To review current knowledge and ongoing debates surrounding PGT-A.
To assess the evolution of PGT-A techniques and their impact on reproductive outcomes.

Main Methods:

Review of current scientific literature on PGT-A.
Analysis of historical and contemporary PGT-A methodologies, including FISH and comprehensive chromosome screening (CCS).
Examination of studies evaluating PGT-A's impact on LBR and cost-effectiveness.

Main Results:

Modern PGT-A primarily utilizes comprehensive chromosome screening on blastocyst biopsies.
The clinical benefit and cost-effectiveness of PGT-A remain subjects of significant debate within the scientific community.

Conclusions:

While PGT-A technology has advanced, its definitive role in improving IVF success requires further investigation.
Ongoing research is crucial to establish the true value of PGT-A in assisted reproductive technologies.