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Vincristine effect on methotrexate cerebrospinal fluid concentration.
Cancer Treatment Reports
|January 1, 1979
Summary
High-dose methotrexate-citrovorum factor treatment effectively cleared meningeal lymphomatosis in a lymphoma patient. Vincristine administration boosted methotrexate levels in cerebrospinal fluid, enhancing treatment efficacy.
Area of Science:
- Oncology
- Pharmacology
Background:
- Malignant lymphoma can spread to the meninges, causing meningeal lymphomatosis.
- High-dose chemotherapy is a treatment option for advanced lymphoma.