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Antiaging Therapies, Cognitive Impairment, and Dementia

Devin Wahl1,2, Rozalyn M Anderson3,4, David G Le Couteur1,2

  • 1Charles Perkins Centre.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|May 25, 2019
PubMed

Insights

Aging accelerates dementia risk. Targeting aging pathways with specific compounds may offer new therapeutic strategies for dementia prevention and treatment by promoting healthier brain aging.

Area of Science:

  • Gerontology
  • Neuroscience
  • Pharmacology

Background:

  • Aging is a primary risk factor for chronic diseases, including dementia.
  • Current dementia treatments targeting disease models are limited.
  • The aging process itself is emerging as a potential therapeutic target for dementia.

Purpose of the Study:

  • To explore the potential of targeting the aging process for dementia treatment and prevention.
  • To review anti-aging compounds and their effects on brain aging and dementia risk.

Main Methods:

  • Review of existing research on cellular and molecular pathways implicated in aging.
  • Analysis of studies on compounds designed to slow aging and extend lifespan.
  • Evaluation of evidence for the impact of anti-aging agents on brain aging.

Main Results:

  • Numerous cellular and molecular pathways are linked to aging.
  • Several compounds show promise in slowing aging and increasing lifespan in animal models.
  • Emerging evidence suggests some anti-aging compounds may benefit brain aging.

Conclusions:

  • Targeting fundamental aging processes offers a novel approach to dementia prevention.
  • Anti-aging compounds may hold potential for mitigating age-related cognitive decline.
  • Further research into anti-aging interventions could lead to new dementia therapies.
Keywords:
Brain agingCaloric restrictionCognitionHealthLife span extension

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