Inverted papilloma with multifocal attachment is associated with increased recurrence

Related Experiment Video

Updated: Jan 24, 2026

Multifocal Electroretinograms
16:49

Multifocal Electroretinograms

Published on: December 4, 2011

18.9K

Charles C L Tong1, Neil N Patel1, Ivy W Maina1

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA.

International Forum of Allergy & Rhinology
|May 25, 2019
PubMed
Abstract

Insights

Primary resection of inverted papilloma (IP) and single-focus attachment reduce recurrence rates. This study analyzed 210 patients, finding lower recurrence in primary surgeries compared to repeat procedures.

Area of Science:

  • Otorhinolaryngology
  • Oncology
  • Surgical Pathology

Background:

  • Inverted papilloma (IP) is a benign sinonasal tumor known for its high recurrence rate, particularly at the bony attachment site.
  • Previous surgical interventions may influence recurrence rates.
  • Understanding factors affecting disease control is crucial for effective management.

Purpose of the Study:

  • To evaluate the recurrence rates of inverted papilloma based on surgical approach (primary vs. secondary resection).
  • To assess the impact of multifocal versus single-focus tumor attachment on disease control.
  • To identify predictors of recurrence in sinonasal inverted papilloma.

Main Methods:

  • Retrospective review of 535 inverted papilloma resections from 2006 to 2016 at a tertiary-care center.
  • Analysis of demographic data, tumor location, attachment sites, and postoperative surveillance.
  • Statistical analysis to determine the effect of surgical history and attachment patterns on recurrence.

Main Results:

  • A total of 210 patients were analyzed with a mean follow-up of 36.4 months.
  • Patients undergoing primary surgery at the institution had a lower recurrence rate (12.4%) compared to those with prior procedures elsewhere (22.3%).
  • Multifocal tumor attachment sites significantly increased the risk of recurrence (OR, 3.5; p = 0.002).

Conclusions:

  • Primary resection of inverted papilloma is associated with a lower recurrence rate.
  • Single-focus tumor attachment is a favorable prognostic factor for disease control.
  • These findings emphasize the importance of surgical history and attachment characteristics in managing sinonasal inverted papilloma.
Keywords:
attachment siteinverted papillomamultifocalprognosisrecurrence

More Related Videos

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy05:25

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy

Published on: October 24, 2025

444
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.7K

Related Concept Videos

Inverting and Non-inverting OpAmps01:20

Inverting and Non-inverting OpAmps

In an inverting amplifier, the input voltage is connected through a resistor to the inverting terminal. Meanwhile, the non-inverting terminal is grounded and a feedback resistor is established between the inverting and output terminal, as depicted in Figure 1.
1.8K
Attachment01:20

Attachment

Attachment is vital for infant development, as warm social interactions support growth and well-being. In a classic 1958 study by Harry Harlow, the significance of warmth and comfort in forming attachments was examined. Harlow separated newborn monkeys from their mothers and provided two artificial "mothers": one made of cold wire and the other covered in soft cloth. Despite the wire mother offering food, the infant monkeys preferred the comfort of the cloth mother, demonstrating that...
518
Attachment Styles01:24

Attachment Styles

Jeffrey Simpson's attachment theory suggests that early caregiver relationships shape lasting patterns of behavior and emotional regulation, known as attachment styles. These patterns are organized along two key dimensions: self-esteem and interpersonal trust. The intersection of these dimensions produces four primary attachment styles that typically persist throughout life and significantly influence how individuals form and maintain relationships.Secure Attachment StyleIndividuals with a...
413
Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall...
4.0K
Theory of Romantic Attachment in Adulthood03:34

Theory of Romantic Attachment in Adulthood

Attachment is a long-standing connection or bond with others. While Attachment Theory was conceived in developmental psychology to describe infant-caregiver bonding, it's been extended into adulthood to include romantic relationships. 
48.7K
Relationship with Parents: Attachment01:28

Relationship with Parents: Attachment

Parent-child interactions lay the foundation for how we understand relationships throughout life. These interactions are not uniform across families; instead, they are shaped by a range of environmental, emotional, and behavioral factors unique to each caregiver-child dynamic. Social psychologists study these early relationships to understand how patterns formed in infancy influence social functioning and interpersonal behavior in adulthood.Attachment Theory and Early Relational ModelsJohn...
232