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Related Experiment Video

Updated: Jan 24, 2026

Technique to Target Microinjection to the Developing Xenopus Kidney

Technique to Target Microinjection to the Developing Xenopus Kidney

Published on: May 3, 2016

PTK7 proteolytic fragment proteins function during early Xenopus development.

Hava Lichtig¹, Yasmin Cohen¹, Naama Bin-Nun¹

¹Department of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, 31096, Israel.

Developmental Biology

|May 25, 2019

Summary

This summary is machine-generated.

Smaller fragments of Protein Tyrosine Kinase 7 (PTK7) effectively regulate Wnt signaling and LRP6 protein levels. These findings demonstrate that PTK7 fragments can mimic full-length PTK7 activity in vertebrate development.

Keywords:

Canonical Wnt signaling LRP6 protein Non-canonical Wnt signaling PTK7 protein Xenopus

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Last Updated: Jan 24, 2026

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Area of Science:

Developmental Biology
Molecular Biology
Cancer Biology

Background:

Protein Tyrosine Kinase 7 (PTK7) is crucial for embryonic development and cancer.
PTK7 regulates both canonical and non-canonical Wnt signaling pathways.
PTK7 activity is linked to nervous system development and human cancer formation.

Purpose of the Study:

To investigate the biological activity of carboxyl-terminal PTK7 proteolytic fragments (cPTK7 622-1070 and cPTK7 726-1070).
To determine if these fragments can recapitulate the functions of full-length PTK7 during early Xenopus nervous system development.

Main Methods:

Studied the effects of specific PTK7 fragments (cPTK7 622-1070, cPTK7 726-1070) in Xenopus laevis embryos.
Assessed the impact of these fragments on canonical Wnt signaling and LRP6 protein levels.
Compared the activity of PTK7 fragments to full-length PTK7 protein.

Main Results:

The examined PTK7 proteolytic fragments (cPTK7 622-1070 and cPTK7 726-1070) demonstrated significant biological activity.
These fragments promoted canonical Wnt signaling by regulating LRP6 protein levels, similar to full-length PTK7.
In vivo evidence confirmed that smaller PTK7 fragments can replicate full-length PTK7 activity in vertebrate development.

Conclusions:

Carboxyl-terminal PTK7 fragments retain the ability to modulate Wnt signaling and LRP6 levels.
These findings highlight the functional relevance of PTK7 fragments in vertebrate nervous system development.
PTK7 fragments may serve as functional mimics of the full-length protein in developmental contexts.