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The perirhinal cortex supports spatial intertemporal choice stability.

M A Kreher1, S A Johnson1, J-M Mizell2

  • 1McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, United States.

Neurobiology of Learning and Memory
|May 25, 2019
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Summary
This summary is machine-generated.

The perirhinal cortex (PRC) is crucial for decision-making under uncertainty. Inactivating the PRC impaired rats' ability to stabilize reward choices, suggesting its role in integrating memory and reward value.

Keywords:
CognitionDecision makingDeliberationMedial temporal lobeRat

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Area of Science:

  • Neuroscience
  • Decision Science
  • Cognitive Science

Background:

  • Optimizing decisions requires integrating past experiences and future predictions, involving memory and reward valuation.
  • The perirhinal cortex (PRC) is anatomically positioned to integrate memory, reward valuation, and prediction due to its connections with key brain regions.
  • The PRC's specific role in value-based decision-making remains under-explored.

Purpose of the Study:

  • To investigate the role of the perirhinal cortex (PRC) in value-based decision-making.
  • To examine how PRC function influences the ability to adapt choices based on variable reward delays.

Main Methods:

  • Utilized a spatial delay discounting task in rats, offering choices between immediate small rewards and delayed large rewards.
  • Inactivated the PRC bilaterally using muscimol and observed behavioral changes in decision-making strategies.
  • Quantified successful exploitation (stabilizing delay) and vicarious trial and error (VTE) events during decision-making.

Main Results:

  • PRC inactivation significantly reduced the rats' ability to exploit, i.e., stabilize delay for the large reward.
  • Inactivation of the PRC led to an increase in vicarious trial and error (VTE) events at the choice point.
  • These findings indicate impaired stability in linking choices to reward outcomes following PRC inactivation.

Conclusions:

  • The perirhinal cortex (PRC) plays a critical role in maintaining stable value-based decisions when facing variable costs.
  • PRC function is essential for integrating reward information and memory to guide adaptive choice behavior.
  • The study highlights the PRC as a key hub for complex decision-making processes involving reward and temporal factors.