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PBPK modeling coupled with biorelevant dissolution to forecast the oral performance of amorphous solid dispersion

Atsushi Kambayashi1, Tsuyoshi Kiyota2, Maya Fujiwara2

  • 1Pharmaceutical Research and Technology Labs, Astellas Pharma Inc., 180 Ozumi, Yaizu, Shizuoka 425-0072, Japan; Institute of Pharmaceutical Technology, Goethe University Frankfurt am Main, Max-von-Laue Straße 9, D-60438 Frankfurt am Main, Germany.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|May 25, 2019
PubMed

Keywords:
Amorphous solid dispersionBiorelevant dissolutionIn silico modeling and simulationOral drug absorptionPharmacokineticsPrecipitation

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