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Stress-induced adaptive morphogenesis in bacteria.

Eveline Ultee1, Karina Ramijan1, Remus T Dame2

  • 1Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, the Netherlands; Centre for Microbial Cell Biology, Leiden University, Leiden, the Netherlands.

Advances in Microbial Physiology
|May 26, 2019
PubMed
Summary
This summary is machine-generated.

Bacteria adapt to stress by changing shape, a process called morphogenesis. This adaptation helps them survive environmental challenges and evade treatments like antibiotics, offering new targets for combating bacterial infections.

Keywords:
AdaptationCell shapeCell wall-deficient cellsFilamentationMorphogenesisNucleoid organizationSporulationStalksStressSwarmingVBNC cells

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Area of Science:

  • Microbiology
  • Cell Biology
  • Bacterial Pathogenesis

Background:

  • Bacteria inhabit diverse environments and face numerous stresses.
  • Cellular adaptation is crucial for survival under adverse conditions.

Purpose of the Study:

  • To describe bacterial coping mechanisms under stress.
  • To explain how stress leads to morphological changes in bacteria.
  • To highlight the implications of stress-induced morphogenesis for pathogenicity and treatment.

Main Methods:

  • This chapter focuses on the biological processes of stress response and cellular adaptation in bacteria.
  • It reviews existing knowledge on how environmental factors induce changes in bacterial cell morphology.

Main Results:

  • Bacteria exhibit significant morphological changes in response to various stresses.
  • These stress-induced morphological alterations can enhance bacterial survival against environmental insults.
  • Pathogenic bacteria utilize these changes to evade host immune responses and antibiotic treatments.

Conclusions:

  • Understanding stress-induced morphogenesis is key to developing novel strategies against bacterial pathogens.
  • Targeting these adaptive mechanisms could lead to more effective treatments for bacterial infections.