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Related Concept Videos

Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the lytic replication...
Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
Viral Replication: Lytic Cycle01:20

Viral Replication: Lytic Cycle

Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects its...
DNA Bacteriophages01:26

DNA Bacteriophages

Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
Bacteriophages of the Human Virome01:23

Bacteriophages of the Human Virome

Bacteriophages are found throughout the human body. They may even outnumber eukaryotic viruses, forming an important and dynamic component of the human virome. Indeed, phages represent the most abundant viral entities, with densities in the gut reaching up to 10⁹ particles per gram of fecal matter, and many belonging to orders such as Caudovirales and Microviridae, while a substantial proportion remains unclassified as viral “dark matter.”Lysogeny and Genetic ExchangeIn the gut, bacteriophages...

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Voprosy virusologii·2022
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[NOVEL APPROACH TO COMPOSITION OF, BACTERIOPHAGE MIXTURES FOR ANTIBACTERIAL THERAPY].

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Related Experiment Video

Updated: Jul 10, 2026

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
07:22

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings

Published on: August 19, 2021

Bacteriophage's Dualism in Therapy.

V N Krylov1, M V Bourkaltseva1, E A Pleteneva1

  • 1I.I. Mechnikov Research Institute for Vaccines and Sera, Moscow 105064, Russia.

Trends in Microbiology
|May 26, 2019
PubMed
Summary

Selecting bacteriophages for phage therapy is crucial to prevent adverse effects. This study compares broad-spectrum phage mixtures with personalized

Area of Science:

  • Microbiology
  • Virology
  • Biotechnology

Background:

  • Phage therapy offers an alternative to antibiotics for bacterial infections.
  • The selection of bacteriophages is critical for therapeutic efficacy and safety.
  • Current strategies range from broad-spectrum mixtures to personalized approaches.

Purpose of the Study:

  • To compare different bacteriophage selection strategies for phage therapy.
  • To highlight the implications of phage selection on therapeutic outcomes.
  • To inform the development of optimized phage therapy protocols.

Main Methods:

  • Comparative analysis of existing phage therapy approaches.
  • Review of literature on bacteriophage selection and application.
  • Evaluation of 'multispecies phage mixtures' versus 'magistral phage' strategies.
Keywords:
phage mixturesphage therapytransposable phages

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T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo
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T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo

Published on: January 26, 2024

Bacteriophage Removal from Infected Salmonella Cultures
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Bacteriophage Removal from Infected Salmonella Cultures

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Related Experiment Videos

Last Updated: Jul 10, 2026

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
07:22

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings

Published on: August 19, 2021

T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo
08:46

T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo

Published on: January 26, 2024

Bacteriophage Removal from Infected Salmonella Cultures
07:19

Bacteriophage Removal from Infected Salmonella Cultures

Published on: June 28, 2024

Main Results:

  • Multispecies phage mixtures offer broad-spectrum activity but may lack specificity.
  • 'Magistral phage' selection allows for tailored treatment but requires individual patient assessment.
  • The choice of strategy impacts the risk of undesirable consequences.

Conclusions:

  • Careful bacteriophage selection is essential for successful phage therapy.
  • Both broad-spectrum and personalized approaches have distinct advantages and disadvantages.
  • Further research is needed to optimize bacteriophage selection for diverse clinical applications.