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Thomas M. Jessell (1951-2019).

Silvia Arber1,2, James Briscoe3

  • 1Biozentrum, Department of Cell Biology, University of Basel, 4056 Basel, Switzerland silvia.arber@unibas.ch james.briscoe@crick.ac.uk.

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Thomas Jessell transformed neuroscience by revealing how neuronal cell types develop and function. His work reshaped our understanding of movement control in the nervous system.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Thomas M. Jessell's research significantly advanced the understanding of neuronal development and function.
  • His work focused on the mechanisms programming neuronal cell type identity during development.
  • These developmental processes dictate neuronal function within the adult nervous system, particularly in movement control.

Discussion:

  • This remembrance highlights Jessell's pivotal contributions to neuroscience.
  • His research fundamentally altered perspectives on neuronal circuit function.
  • The focus is on his impact on understanding the motor nervous system.

Key Insights:

  • Jessell elucidated how genetic and molecular mechanisms establish specific neuronal identities.
  • His findings provided a framework for understanding how these identities relate to function.
  • This revolutionized the study of neural circuits underlying movement.

Outlook:

  • Continued exploration of developmental programming in neural circuits.
  • Further understanding of how developmental pathways influence adult nervous system function.
  • Applying Jessell's foundational principles to neurological disorders and regenerative medicine.