Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Common Ion Effect03:24

Common Ion Effect

46.1K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
46.1K
Variability: Analysis01:11

Variability: Analysis

471
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
471
Random Variables01:09

Random Variables

17.6K
A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.6K
Variables Affecting Phosphorescence and Fluorescence01:26

Variables Affecting Phosphorescence and Fluorescence

1.3K
Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...
1.3K
What is the Immune System?01:38

What is the Immune System?

127.2K
Overview
127.2K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

736
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
736

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variations in the Adult Rheumatology Fellowship Training in the United States: Opportunities and Challenges.

Arthritis care & research·2026
Same author

Glycolysis-dependent sulfur metabolism orchestrates morphological plasticity and virulence in fungi.

eLife·2026
Same author

Evaluating Risk Factors for Severe Renin-Angiotensin-Aldosterone System Inhibitor Induced Angioedema.

The Laryngoscope·2025
Same author

Best Practices for Addressing Differences in Antimicrobial Resistance Through Quality Improvement Projects in Antimicrobial Stewardship in Low-Resource Settings.

Mayo Clinic proceedings·2025
Same author

Pneumococcal and Herpes Zoster Vaccination Rates Among U.S. Veterans With Chronic Inflammatory Disease on Biologic Medications: A Quality Improvement Project.

Military medicine·2025
Same author

Axial Spondyloarthritis in Black Americans: An Observational Study From Five Centers in Shelby County, Tennessee.

ACR open rheumatology·2024
Same journal

Independent Prognostic Contributions of Anti-Ro52 and Anti-MDA5 in Autoimmune-Associated Interstitial Lung Disease.

Chest·2026
Same journal

Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

Chest·2026
Same journal

Lung Cancer Incidence and Mortality after Negative Low-Dose CT Screening Results.

Chest·2026
Same journal

Symptom prevalence and impact on lung cancer risk in the SUMMIT study.

Chest·2026
Same journal

How I Do It: De-escalation of Prostacyclin-Based Therapy in Patients Treated With Sotatercept.

Chest·2026
Same journal

Eisenmenger Syndrome: The Pulmonology Perspective.

Chest·2026
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
07:55

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

12.2K

Common Variable Immune Deficiency and Associated Complications.

Siddhi Gupta1, Debendra Pattanaik2, Guha Krishnaswamy3

  • 1Department of Medicine, Division of Infectious Disease, Wake Forest School of Medicine, Winston Salem, NC.

Chest
|May 26, 2019
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) is a primary immune deficiency causing infections and inflammation due to poor antibody production. Management focuses on immunoglobulin replacement and treating diverse complications like lung disease and autoimmunity.

Keywords:
IVIGasthmabronchiectasiscommon variable immune deficiencygranulomahypogammaglobulinemialiver diseaselymphadenopathymalignancynodular lymphoid hyperplasiasarcoidosissplenomegaly

More Related Videos

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

8.3K
A Rapid Method for Modeling a Variable Cycle Engine
04:58

A Rapid Method for Modeling a Variable Cycle Engine

Published on: August 13, 2019

8.0K

Related Experiment Videos

Last Updated: Jan 24, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
07:55

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

12.2K
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

8.3K
A Rapid Method for Modeling a Variable Cycle Engine
04:58

A Rapid Method for Modeling a Variable Cycle Engine

Published on: August 13, 2019

8.0K

Area of Science:

  • Immunology
  • Pulmonology

Background:

  • Common variable immunodeficiency disorders (CVID) are frequent primary immune deficiencies.
  • They manifest with infectious and inflammatory issues from impaired antibody production and sometimes cellular immunity.

Purpose of the Study:

  • To review molecular aspects, diagnosis, presentations, and management of CVID.
  • To update understanding for clinicians, especially pulmonologists dealing with CVID sequelae.

Main Methods:

  • Literature review of CVID molecular mechanisms.
  • Analysis of diagnostic criteria and clinical presentations.
  • Synthesis of current therapeutic strategies and complication management.

Main Results:

  • CVID presents with recurrent sinopulmonary infections, bronchiectasis, and autoimmune disorders.
  • Malignancies, GI diseases, and granulomatous lung disease are also common complications.
  • Immunoglobulin infusion is the primary therapy, but managing complications can be challenging.

Conclusions:

  • CVID requires a multidisciplinary approach for effective management.
  • Understanding molecular underpinnings aids in diagnosis and targeted therapies.
  • Early recognition and management of complications are crucial for patient outcomes.