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Updated: Jan 24, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
Long-term biodistribution and toxicity of curcumin capped iron oxide nanoparticles after single-dose administration
Nihal Saad Elbialy1, Samia Faisal Aboushoushah2, Wafa Wuqayyan Alshammari3
1Medical Physics Program, Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Biophysics, Faculty of Science, Cairo University, Egypt.
Aim:
In this study, in vivo biodistribution, clearness and toxicity of curcumin capped iron oxide nanoparticles (Cur-IONPs) were addressed in different body organs.
Materials And Methods:
The physicochemical properties of the prepared Cur-IONPs were investigated. Long term (3 weeks) biodistribution, clearness and toxicity were assessed for a single-dose administration of Cur-IONPs (5 mg/kg). The iron content in liver, kidney, spleen and brain was quantified using atomic absorption spectroscopy. Serum biochemical parameters were also measured.
Key Findings:
The integrated in vivo results demonstrated that Cur-IONPs was mostly taken up in the liver and spleen reaching its highest levels on days 1 and 2, respectively. In the brain, the results showed significant accumulation of Cur-IONPs between 1 h to 1-day post injection. This represented the successful penetration Cur-IONPs across the blood-brain barrier. Serum biochemical analysis demonstrated a temporal disturbance in the performance of body organs. Also, the body weights showed no alteration throughout the experiment.
Significance:
It has been deduced that the promising green synthesized Cur-IONPs as an "All in One" nanoplatform is safe enough to be used in diagnostic and therapeutic purposes.
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