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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
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Related Experiment Video

Updated: Jan 24, 2026

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
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Predicting Transfusions During Left Ventricular Assist Device Implant.

Robert J H Miller1, Alexander J Gregory2, William Kent3

  • 1Division of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada; Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, and Department of Medicine, Stanford University, Stanford, California.

Seminars in Thoracic and Cardiovascular Surgery
|May 26, 2019
PubMed
Summary
This summary is machine-generated.

Perioperative transfusions are common in left ventricular assist device (LVAD) patients, increasing risks. Elevated central venous pressure and anemia are key factors linked to early packed red blood cell (PRBC) transfusions.

Keywords:
BleedingLeft ventricular assist deviceLvadPeri-operative carePost-operative care

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Area of Science:

  • Cardiology
  • Transfusion Medicine
  • Surgical Outcomes

Background:

  • Perioperative bleeding and transfusion are significant complications in patients undergoing left ventricular assist device (LVAD) implantation, contributing to morbidity and mortality.
  • Understanding factors associated with blood product transfusions and their clinical impact is crucial for improving patient outcomes.

Purpose of the Study:

  • To identify factors associated with packed red blood cell (PRBC) and other blood product transfusions within 30 days of durable LVAD implantation.
  • To evaluate the clinical outcomes linked to perioperative blood product transfusions in LVAD recipients.

Main Methods:

  • A retrospective cohort study analyzed 156 patients who underwent initial durable LVAD implantation between 2014 and 2016.
  • Ordinal multivariable regression was used to determine factors independently associated with transfusion rates.
  • Data on transfusions (PRBC, platelets, fresh frozen plasma) and patient characteristics were collected and analyzed.

Main Results:

  • Patients received a mean of 11.7 units of PRBC and 10.0 units of other products within 30 days.
  • Factors associated with increased PRBC transfusion included preimplant mechanical ventilation, dialysis, higher INR, previous sternotomy, higher MELD score, and lower hemoglobin.
  • Higher preoperative central venous pressure, mechanical ventilation, concomitant procedures, previous sternotomy, and lower hemoglobin were linked to early PRBC transfusion (within 48 hours).
  • Transfusions correlated with longer ventilation duration, ICU stay, reoperation for bleeding, and all-cause mortality.

Conclusions:

  • Perioperative blood product exposure is frequent in LVAD patients and is associated with worse clinical outcomes.
  • Elevated central venous pressure and anemia are potentially modifiable factors contributing to increased early PRBC transfusion rates.
  • Strategies targeting these factors may help reduce transfusion requirements and improve outcomes in LVAD recipients.