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Post Column Derivatization Using Reaction Flow High Performance Liquid Chromatography Columns
Published on: April 26, 2016
Derivatization approaches and applications of pullulan
Sanjay Tiwari1, Rahul Patil1, Sunil K Dubey2
1Maliba Pharmacy College, UKA Tarsadia University, Gopal-Vidyanagar Campus, Surat 394350, Gujarat, India.
Abstract:
Pullulan (PUL), a linear exo-polysaccharide, is useful in industries as diverse as food, cosmetics and pharmaceuticals. PUL presents many favorable characteristics, such as renewable origin, biocompatibility, stability, hydrophilic nature, and availability of reactive sites for chemical modification. With an inherent affinity to asialoglycoprotein receptors, PUL can be used for targeted drug delivery to the liver. Besides, these primary properties have been combined with modern synthetic approaches for developing multifunctional biomaterials. This is evident from numerous studies on approaches, such as hydrophobic modification, cross-linking, grafting and transformation as a polyelectrolyte. In this review, we have discussed up-to-date advances on chemical modifications and emerging applications of PUL in targeted theranostics and tissue engineering. Besides, we offer an overview of its applications in food, cosmetics and environment remediation.
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