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Derivatization approaches and applications of pullulan
Sanjay Tiwari1, Rahul Patil1, Sunil K Dubey2
1Maliba Pharmacy College, UKA Tarsadia University, Gopal-Vidyanagar Campus, Surat 394350, Gujarat, India.
Advances in Colloid and Interface Science
|May 26, 2019
Summary
Pullulan (PUL), a biocompatible polysaccharide, offers versatile applications due to its unique properties. Chemical modifications enhance PUL
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Pullulan (PUL) is a linear, renewable exo-polysaccharide with inherent biocompatibility and stability.
- Its hydrophilic nature and reactive sites facilitate chemical modifications for advanced applications.
- PUL's affinity for asialoglycoprotein receptors enables targeted liver drug delivery.
Purpose of the Study:
- To review recent advances in chemical modifications of pullulan.
- To explore emerging applications of modified pullulan in theranostics and tissue engineering.
- To provide an overview of pullulan's use in food, cosmetics, and environmental remediation.
Main Methods:
- Literature review of chemical modifications: hydrophobic modification, cross-linking, grafting, and polyelectrolyte transformation.
- Analysis of studies focusing on pullulan-based biomaterials for theranostics and tissue engineering.
- Compilation of data on pullulan's applications in food, cosmetics, and environmental sectors.
Main Results:
- Chemical modifications significantly enhance pullulan's functionality for diverse applications.
- Modified pullulan shows promise in targeted drug delivery, theranostics, and tissue engineering.
- Pullulan is effectively utilized in food, cosmetics, and environmental remediation.
Conclusions:
- Pullulan is a highly adaptable biomaterial with extensive potential in advanced scientific and industrial fields.
- Ongoing research in chemical modification and application development continues to expand pullulan's utility.
- Pullulan represents a sustainable and effective material for various technological innovations.
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